Skip to content

Sleep and Chronobiology

Category: sleep

  • Home
  • sleep
Cyclobenzaprine and Sleep Architecture
deep sleep pharmacology REM sleep sleep architecture

Cyclobenzaprine and Sleep Architecture

Cyclobenzaprine, a centrally acting muscle relaxant structurally related to tricyclic antidepressants, demonstrates significant effects on sleep architecture beyond its primary indication for muscle spasm relief. Research reveals that this medication…
by jakejb May 23, 2025
Supplements that Enhance Deep (Slow-Wave) Sleep and REM Sleep
deep sleep pharmacology REM sleep sleep architecture supplements

Supplements that Enhance Deep (Slow-Wave) Sleep and REM Sleep

Deep (slow-wave) sleep (SWS) and REM sleep are critical for recovery, memory and metabolic health. Certain supplements and compounds can selectively increase these stages. Below we review key agents with…
by jakejb April 30, 2025May 23, 2025
Glycine and Sleep: A Deep Dive
sleep supplements

Glycine and Sleep: A Deep Dive

Mechanisms of Glycine in Sleep Thermoregulation via SCN: Glycine promotes sleep partly by lowering core body temperature through peripheral vasodilation. Research in rats showed that oral glycine triggered non-REM sleep…
by jakejb April 26, 2025April 26, 2025
Non-Prescription Orexin Receptor Antagonists and Suppressors
pharmacology sleep

Non-Prescription Orexin Receptor Antagonists and Suppressors

Introduction Orexin-A and orexin-B (also called hypocretins) are neuropeptides that promote wakefulness, arousal, and appetite by acting on orexin-1 (OX1R) and orexin-2 (OX2R) receptors in the brain (SB-334867 – Wikipedia).…
by jakejb April 26, 2025April 26, 2025
Trazodone’s Effects on Circadian Rhythms and Sleep
chronobiology pharmacology sleep

Trazodone’s Effects on Circadian Rhythms and Sleep

Clinical Findings: Sleep Architecture and Circadian Parameters Table: Selected Studies on Trazodone’s Effects on Sleep & Circadian Rhythms Study (Population) Design (Dose & Duration) Key Outcomes Nakamura et al. 2002…
by jakejb April 26, 2025April 26, 2025
Pharmacological Approaches to Phase-Advance Sleep and Stabilize Circadian Rhythm
chronobiology pharmacology sleep

Pharmacological Approaches to Phase-Advance Sleep and Stabilize Circadian Rhythm

Circadian rhythm sleep disorders like Delayed Sleep-Wake Phase Disorder (DSWPD) involve a misalignment of the internal clock with desired sleep times. Pharmacological agents can help advance the sleep phase (shift…
by jakejb April 26, 2025April 26, 2025
Classes of Hypnotic Medications: Past, Present, and Future
pharmacology sleep

Classes of Hypnotic Medications: Past, Present, and Future

Insomnia medications (“sleeping pills”) can be categorized by mechanism of action into distinct classes. Below we outline all known classes of hypnotics – including those historically used (past), currently prescribed…
by jakejb April 26, 2025April 26, 2025

Recent Posts

  • Cyclobenzaprine and Sleep Architecture
  • Supplements that Enhance Deep (Slow-Wave) Sleep and REM Sleep
  • Glycine and Sleep: A Deep Dive
  • Non-Prescription Orexin Receptor Antagonists and Suppressors
  • Trazodone’s Effects on Circadian Rhythms and Sleep

Recent Comments

No comments to show.

Archives

  • May 2025
  • April 2025

Categories

  • chronobiology
  • deep sleep
  • pharmacology
  • REM
  • sleep
  • sleep architecture
  • supplements
Theme: Blog Paper By Artify Themes.